Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B3 All Species: 32.73
Human Site: S133 Identified Species: 48
UniProt: Q15393 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q15393 NP_036558.3 1217 135577 S133 K G R A V M I S A I E K Q K L
Chimpanzee Pan troglodytes XP_511081 1283 142840 S199 K G R A V M I S A I E K Q K L
Rhesus Macaque Macaca mulatta XP_001107025 1199 133593 N127 Q K L V Y I L N R D A A A R L
Dog Lupus familis XP_536791 1217 135545 S133 K G R A V M I S A I E K Q K L
Cat Felis silvestris
Mouse Mus musculus Q921M3 1217 135532 S133 K G R A V M I S A I E K Q K L
Rat Rattus norvegicus XP_001077410 1216 135436 S133 K G R A V M I S A I E K Q K L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506454 1217 135474 S133 K G R A V M I S A I E K Q K L
Chicken Gallus gallus XP_001232348 1218 135585 S133 K G R A V M I S A I E K Q K L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q1LVE8 1217 135603 G133 K G R A V M I G A T E K Q K L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_728546 1227 136598 G133 K G R A V M I G A V E K Q K L
Honey Bee Apis mellifera XP_623333 1217 135272 G133 K G R A V M I G A I E K Q K L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188711 1141 126889 Q126 D P T G E A A Q A T Q Q L L T
Poplar Tree Populus trichocarpa XP_002312063 1213 134429 G132 K G R A V M I G A C E K Q K L
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana O49552 1088 121161 E95 C V L Q W D Y E S S E L I T R
Baker's Yeast Sacchar. cerevisiae Q04693 1361 153766 T182 V N Q P L T R T T L R R V S P
Red Bread Mold Neurospora crassa Q7RYR4 1209 134021 S139 K G R A C L I S A L E K N K L
Conservation
Percent
Protein Identity: 100 94.8 98.1 99.9 N.A. 99.9 99.5 N.A. 99.6 99 N.A. 93.4 N.A. 75.4 80.5 N.A. 76.1
Protein Similarity: 100 94.8 98.2 100 N.A. 100 99.5 N.A. 99.9 99.6 N.A. 97.9 N.A. 86.9 90.2 N.A. 85.7
P-Site Identity: 100 100 6.6 100 N.A. 100 100 N.A. 100 100 N.A. 86.6 N.A. 86.6 93.3 N.A. 6.6
P-Site Similarity: 100 100 40 100 N.A. 100 100 N.A. 100 100 N.A. 86.6 N.A. 93.3 93.3 N.A. 20
Percent
Protein Identity: 58.7 N.A. N.A. 23.5 23 51
Protein Similarity: 76.1 N.A. N.A. 42 41.5 69.5
P-Site Identity: 86.6 N.A. N.A. 6.6 0 73.3
P-Site Similarity: 86.6 N.A. N.A. 13.3 33.3 86.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 75 0 7 7 0 82 0 7 7 7 0 0 % A
% Cys: 7 0 0 0 7 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 7 0 0 0 7 0 0 0 0 0 % D
% Glu: 0 0 0 0 7 0 0 7 0 0 82 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 75 0 7 0 0 0 25 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 7 75 0 0 50 0 0 7 0 0 % I
% Lys: 75 7 0 0 0 0 0 0 0 0 0 75 0 75 0 % K
% Leu: 0 0 13 0 7 7 7 0 0 13 0 7 7 7 82 % L
% Met: 0 0 0 0 0 69 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 7 0 0 0 0 7 0 0 % N
% Pro: 0 7 0 7 0 0 0 0 0 0 0 0 0 0 7 % P
% Gln: 7 0 7 7 0 0 0 7 0 0 7 7 69 0 0 % Q
% Arg: 0 0 75 0 0 0 7 0 7 0 7 7 0 7 7 % R
% Ser: 0 0 0 0 0 0 0 50 7 7 0 0 0 7 0 % S
% Thr: 0 0 7 0 0 7 0 7 7 13 0 0 0 7 7 % T
% Val: 7 7 0 7 69 0 0 0 0 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _